Creating Waves of Awareness
Brittle Bone Disease ~ Can Homeopathy Help?
When there is a genetic immune deficiency disease, can Homeopathy Help?
WIKIPEDIA | Osteogenesis imperfecta
Osteogenesis imperfecta (OI and sometimes known as Brittle Bone Disease, or "Lobstein syndrome"[1]) is a genetic bone disorder. People with OI are born with defective connective tissue, or without the ability to make it, usually because of a deficiency of Type-I collagen.[2] This deficiency arises from an amino acid substitution of glycine to bulkier amino acids in the collagen triple helix structure. The larger amino acid side-chains create steric hindrance that creates a "bulge" in the collagen complex, which in turn influences both the molecular nanomechanics as well as the interaction between molecules, which are both compromised [3]. As a result, the body may respond by hydrolyzing the improper collagen structure. If the body does not destroy the improper collagen, the relationship between the collagen fibrils and hydroxyapatite crystals to form bone is altered, causing brittleness [4]. Another suggested disease mechanism is that the stress state within collagen fibrils is altered at the locations of mutations, where locally larger shear forces lead to rapid failure of fibrils even at moderate loads as the homogeneous stress state found in healthy collagen fibrils is lost [5]. These recent works suggest that OI must be understood as a multi-scale phenomenon, which involves mechanisms at the genetic, nano-, micro- and macro-level of tissues.
As a genetic disorder, OI is an autosomal dominant defect. Most people with OI receive it from a parent but it can be an individual (de novo or "sporadic") mutation.
OI caused by mutation in the gene LEPRE1 is classified as type VIII. [7]
Bisphosphonates Bisphosphonates (BPs), particularly those containing nitrogen, are being increasingly administered to increase bone mass and reduce the incidence of fracture. BPs can be dosed orally (e.g. alendronate) or by intravenous injection/infusion (e.g. pamidronate,[8] zoledronic acid).
BP therapy is being used increasingly for the treatment of OI. It has proven efficiency in reducing fracture rates in children,[9] however only a trend towards decreased fracture was seen in a small randomized study in adults.[10] While decreasing fracture rates, there is some concern that prolonged BP treatment may delay the healing of OI fractures, although this has not been conclusively demonstrated.
Pamidronate is used in USA, UK and Canada. Some hospitals, such as most Shriners, provide it to children. Some children are under a study of pamidronate. Marketed under the brand name Aredia, Pamidronate is usually administered as an intravenous infusion, lasting about three hours. The therapy is repeated every three to six months, and lasts for the life of the patient. Common side effects include bone pain, low calcium levels, nausea, and dizziness. According to recent results, extended periods of pamidrinate, (i.e.;6 years) can actually weaken bones, so patients are recommended to get bone densities every 6 months-1 year, to monitor bone strength.
Surgery
Metal rods can be surgically inserted in the long bones to improve strength, a procedure developed by Harold A. Sofield, MD, at Shriners Hospitals for Children in Chicago. During the late 1940’s, Sofield, Chief of Staff at Shriners Hospitals in Chicago, worked there with large numbers of children with OI and experimented with various methods to strengthen the bones in these children.[11] In 1959, with Edward A. Miller, MD, Sofield wrote a seminal article describing a solution that seemed radical at the time: the placement of stainless steel rods into the intramedullary canals of the long bones to stabilize and strengthen them. His treatment proved extremely useful in the rehabilitation and prevention of fractures; it was adopted throughout the world and still forms the basis for orthopedic treatment of OI.
Spinal fusion can be performed to correct scoliosis, although the inherent bone fragility makes this operation more complex in OI patients. Surgery for basilar impressions can be carried out if pressure being exerted on the spinal cord and brain stem is causing neurological problems.
Homeopathic Approaches
WIKIPEDIA | Osteogenesis imperfecta
Osteogenesis imperfecta (OI and sometimes known as Brittle Bone Disease, or "Lobstein syndrome"[1]) is a genetic bone disorder. People with OI are born with defective connective tissue, or without the ability to make it, usually because of a deficiency of Type-I collagen.[2] This deficiency arises from an amino acid substitution of glycine to bulkier amino acids in the collagen triple helix structure. The larger amino acid side-chains create steric hindrance that creates a "bulge" in the collagen complex, which in turn influences both the molecular nanomechanics as well as the interaction between molecules, which are both compromised [3]. As a result, the body may respond by hydrolyzing the improper collagen structure. If the body does not destroy the improper collagen, the relationship between the collagen fibrils and hydroxyapatite crystals to form bone is altered, causing brittleness [4]. Another suggested disease mechanism is that the stress state within collagen fibrils is altered at the locations of mutations, where locally larger shear forces lead to rapid failure of fibrils even at moderate loads as the homogeneous stress state found in healthy collagen fibrils is lost [5]. These recent works suggest that OI must be understood as a multi-scale phenomenon, which involves mechanisms at the genetic, nano-, micro- and macro-level of tissues.
As a genetic disorder, OI is an autosomal dominant defect. Most people with OI receive it from a parent but it can be an individual (de novo or "sporadic") mutation.
Type I
Collagen is of normal quality but is produced in insufficient quantities:
- Bones fracture easily
- Slight spinal curvature
- Loose joints
- Poor muscle tone
- Discoloration of the sclera (whites of the eyes), usually giving them a blue-gray color. The blue-gray color of the sclera is due to the underlying choroidal veins which show through. This is due to the sclera being thinner than normal because of the defective Type I Collagen not forming correctly.
- Early loss of hearing in some children
- Slight protrusion of the eyes
IA and IB are defined to be distinguished by the absence/presence of dentinogenesis imperfecta (characterized by opalescent teeth; absent in IA, present in IB). Life expectancy is slightly reduced compared to the general population due to the possibility of fatal bone fractures and complications related to OI Type I such as Basilar invagination.[citation needed]
Type II
Collagen is not of a sufficient quality or quantity
- Most cases die within the first year of life due to respiratory failure or intracerebral hemorrhage
- Severe respiratory problems due to underdeveloped lungs
- Severe bone deformity and small stature
Type II can be further subclassified into groups A, B, C, which are distinguished by radiographic evaluation of the long bones and ribs. Type IIA demonstrates broad and short long bones with broad and beaded ribs. Type IIB demonstrates broad and short long bones with thin ribs that have little or no beading. Type IIC demonstrates thin and longer long bones with thin and beaded ribs.
Type III
Collagen quantity is sufficient but is not of a high enough quality
- Bones fracture easily, sometimes even before birth
- Bone deformity, often severe
- Respiratory problems possible
- Short stature, spinal curvature and sometimes barrel-shaped rib cage
- Loose joints
- Poor muscle tone in arms and legs
- Discolouration of the sclera (the 'whites' of the eyes)
- Early loss of hearing possible
Type III is distinguished among the other classifications as being the "Progressive Deforming" type, wherein a neonate presents with mild symptoms at birth and develops the aforementioned symptoms throughout life. Lifespan may be normal, albeit with severe physical handicapping.
Type IV
Collagen quantity is sufficient but is not of a high enough quality
- Bones fracture easily, especially before puberty
- Short stature, spinal curvature and barrel-shaped rib cage
- Bone deformity is mild to moderate
- Early loss of hearing
Similar to Type I, Type IV can be further subclassified into types IVA and IVB characterized by absence (IVA) or presence (IVB) ofdentinogenesis imperfecta.
Type V
X-Ray OI Type V in Adult X-Ray OI Type V Kid
OI Type V leads to calcification of the membrane between the two forearm bones, making it difficult to turn the wrist. Another symptom is abnormally large amounts of repair tissue (hyperplasic callus) at the site of fractures. At the present time, the cause for Type V is unknown, though doctors have determined that it is inherited.Same clinical features as Type IV. Distinguished histologically by "mesh-like" bone appearance. Further characterized by the "V Triad" consisting of a) radio-opaque band adjacent to growth plates, b) hypertrophic calluses at fracture sites, and c) calcification of the radio-ulnar interosseous membrane [6].
More on Type V Research More on OI Study
[edit]Type VI
Same clinical features as Type IV. Distinguished histologically by "fish-scale" bone appearance.
[edit]Type VII
- In 2005 a recessive form called "Type VII" was discovered. Thus far it seems to be limited to a First Nations people inQuebec For more information see http://www.oif.org/site/DocServer/CRTAP.pdf?docID=4522.
Mutations in the gene CRTAP causes this type. [7]
Type VIII
OI caused by mutation in the gene LEPRE1 is classified as type VIII. [7]
Bisphosphonates Bisphosphonates (BPs), particularly those containing nitrogen, are being increasingly administered to increase bone mass and reduce the incidence of fracture. BPs can be dosed orally (e.g. alendronate) or by intravenous injection/infusion (e.g. pamidronate,[8] zoledronic acid).
BP therapy is being used increasingly for the treatment of OI. It has proven efficiency in reducing fracture rates in children,[9] however only a trend towards decreased fracture was seen in a small randomized study in adults.[10] While decreasing fracture rates, there is some concern that prolonged BP treatment may delay the healing of OI fractures, although this has not been conclusively demonstrated.
Pamidronate is used in USA, UK and Canada. Some hospitals, such as most Shriners, provide it to children. Some children are under a study of pamidronate. Marketed under the brand name Aredia, Pamidronate is usually administered as an intravenous infusion, lasting about three hours. The therapy is repeated every three to six months, and lasts for the life of the patient. Common side effects include bone pain, low calcium levels, nausea, and dizziness. According to recent results, extended periods of pamidrinate, (i.e.;6 years) can actually weaken bones, so patients are recommended to get bone densities every 6 months-1 year, to monitor bone strength.
Surgery
Metal rods can be surgically inserted in the long bones to improve strength, a procedure developed by Harold A. Sofield, MD, at Shriners Hospitals for Children in Chicago. During the late 1940’s, Sofield, Chief of Staff at Shriners Hospitals in Chicago, worked there with large numbers of children with OI and experimented with various methods to strengthen the bones in these children.[11] In 1959, with Edward A. Miller, MD, Sofield wrote a seminal article describing a solution that seemed radical at the time: the placement of stainless steel rods into the intramedullary canals of the long bones to stabilize and strengthen them. His treatment proved extremely useful in the rehabilitation and prevention of fractures; it was adopted throughout the world and still forms the basis for orthopedic treatment of OI.
Spinal fusion can be performed to correct scoliosis, although the inherent bone fragility makes this operation more complex in OI patients. Surgery for basilar impressions can be carried out if pressure being exerted on the spinal cord and brain stem is causing neurological problems.
Homeopathic Approaches
Thank you for listing remedies to begin our search and research for answers
Potency and Repetition Brings Varied Answers
- As we have been discussing in the Placebo thread there is such a thing as cultural differences to how we proceed with treatment.
- Use of low potency in frequent repetition and theory.
- Use of high potency with infrequent repetition.
- Concern for aggravation. Reduction in aggravation.
- Use of cell salts.
- Determining Miasm and how that effects treatment.
- Nutrition, Diet, Supplements, Exercise.
- Building the client / patient relationship and how that effects outcome.
Tags: acid, amino, bisphosphonates, bone, brittle, disease, homeopathy, homeopathy-world-community, imperfect, lobstein
Replies to This Discussion
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Permalink Reply by Yvonne Siblini on -
You should look into Calc-Flour. A good combi of Calc-Flour, Calc-Phos, Sil as an oesteo preparation in low potency.
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Permalink Reply by DR AJAY YADAV on -
i will say CALC-phos 6X WILL REMEDY
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Permalink Reply by Dr Dushyant Kamal Dhari on -
Calcarea Carb, Silicea, Merc sol, Phosphoric acid, Calc -phos, should help at deeper level for this.
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Permalink Reply by Dr. Niel Madhavan on -
The dominant miasms in such cases is Syphilis. Cure is very difficult and often a long process spanning many years. One should be careful with the use of high centecimal potencies in these cases as they may lead to violent aggravations, at times making the situation critical. I have myself been guilty of one such negligence in the early years of my practice. I always use LM potencies in such cases.
The standard rules of treatment remain - Symptom totality should lead to the right remedy covering the dominant miasm. As the ground-soil is always Psora, one will be required to bring to use anti-psoric remedies in alteration with anti-syphilitic ones.
The treatment should be supplemented with tissue salts and the right diet.
Regards
Niel
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Permalink Reply by Dr. Niel Madhavan on
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We will have to agree to disagree here Dr. Rana. My experience suggests otherwise. I have moved to LM potencies and find it give very satisfactory results.
Regarding biochems, Homeopaths always had differences. I never found biochems cause any proving symptoms and treat them as tissue salts to supplemen the process of cure. Combination remedies are if course a strict NO.
Warm regards
Niel
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Permalink Reply by Debby Bruck on -
I believe that most homeopaths provide dosage and potency recommendation on a patient to patient basis, Dr Satish. Thus, if a person is taking many allopathic drugs, it is often recommended to take the remedies in water [LM] daily with renewed succussion to change the potency vibration slightly.
Our systems have to overcome so much environmental pollutions daily, like EMF, food and water toxins, etc. that many people need to repeated dosing.
While, there are others who are so sensitive, the potency must be adjusted and fine-tuned to fit that person's energy without too much aggravation.
I am noticing how many Indian homeopaths utilize the placebo in-between major remedy changes to hold the patient through while 'waiting' for it to act.
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Permalink Reply by Dr. Niel Madhavan on
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Interesting Dr. Rana....could you please let me know when Hahnemann proposed the use of high potencies...he was very critical of the same and is known to have fixed 30c as the higher potency limit. Boenninghausen and others slowly convinced him of higher potency but even he talked of 200 as HIGH potency. I would really like you to quote from wherever you can on how my experiences are against Hahnemann's conclusion. I would be glad to be enlightened on my inadequacies.
All your comments are based on a gross generalization. How do you know my approach of using LMs? It is never to be repeated blindly and I never do so, repetitions happen only when the action of the last dose has ceased. I follow no fixed protocol and hence do not really see the reason for being included in your outburst against the entire world for misusing LMs. I do it because it is very mild in action and deep acting at the same time.
Besides, I talk from the experience of having treated such cases in places where people are terribly under-nourished. I have worked in the least developed villages of Bihar and Orissa for more than two decades and know fully well what i am talking about. Starting with high potencies in such cases can lead to terrible aggravations even with a single dose which becomes very difficult to manage then. Only the strongest of constitutions can bear the effects of a very high potency in the case of a strong miasmatic taint.
Besides, you are forgetting a basic concept of homeopathic posology - which is that potency should be decided on the basis of the strength of constitution and the susceptibility of the patient. Throwing high potencies at any and every case is as non-homeopathic as anything else.
Regards
Niel
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Permalink Reply by Alias Azhar on -
it more to tube maism then syhil maism, peace wasalaman
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Permalink Reply by dr.sadathsait on -
dear doctors
has anyone treated Osteogenesis imperfecta?.I have treated 3 cases of such.from tht experience i can suggest u this .predominent miasm+ constituitional mediciens alone helps. i have treated successfully all thse cases and kids r still under my supervision without any medicines and any breakage of bones.just stick to basics.dont go for the misms of the diseases and pathology alone.go with themiasms of the patient.in my 2 cases they had predominent syphilitci miasm ,with familiar h/o of carcinoma and alcoholism,1 case was sycotic.and constituitional medicine has to be give with proper monitoring and less frequent repetation.ONLYHOMOEOPATHY CAN BRING CAHNGES.NOTHING ELSE
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Permalink Reply by Jonathan Shore MD on -
Good Drs,
Please forgive my entry into this thread as I have nothing to say concerning the pathology being discussed.
I do, however, feel strongly that when we enter into the areas of right and wrong we begin to tread on very thin ice.
Anyone can quote from theory and if the argument is simply about theory - what was said by whom and when, then right and wrong is easy to establish.
On the other hand when the discussion concerns actually experienced clinical results then the entry of right and wrong into the debate becomes really destructive.
Thus I feel it is really important to distinguish between these two forms of discussion
1] The what the theory says and
2] The what my actual experience has been.
Now it is possible to honestly discuss the relationship between these 2 and then we can all benefit.
Again, my apologies for entering into this thread as I do not know any of the contributors and am just using it as a forum to spread my opinion that strife amongst homeopaths is a much worse enemy than the allopaths or wrong prescribing.
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Permalink Reply by Debby Bruck on
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Jonathan ~ everyone is welcome to post comments in any discussion on HWC. There are no limits. We all benefit the more people write in on blogs and forums. That is the whole purpose of social networks and by showing an interest, you become a model citizen for others to 'have their say".
Now, if a person repeats them self over and over again with the exact same message everywhere, without making a pertinent statement related to the issue at hand, then this is considered spam.
On other websites you are given the ability to RATE an article. By doing this, you create BUZZ and more activity to a particular article, which brings in more readers. We always welcome your thoughts. May many follow in your footsteps, even if it is to agree or disagree upon a point of view or topic area.
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Permalink Reply by dr.sadathsait on
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in selection of miasms pathology also plays big role,and in diferent persons distructions takes different pattern,in some breakage becomes extensive andin some its little delayed means not small injuries gives breakage of bones and the fracture doesnt become too extensive.and familial history,patients history of past etc helps in seletion of medciine as well asmiasm.
yes.dr.rana said it right.right medicine taking all the aspect of patient and diseases is called deep acting constituitional medicine.there is acute medicines which has to be given in times of need.tht is also selected on totality of tht time.give him the right medicine for the total symptoms of patient taking care of every aspect of the patient
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