Temperature at Homeopathic Medicine Will Destroy

Hello Everyone 

I am saying thanks in advance if anyone knows about this topic. I did not find any research based article.

"At what temperature Homeopathic Medicines will destroy" 

1.  40-50 degree C

2.  50-70 degree C

3.  70-80 degree C 

4.  above 80 degree C 

Please share your views