No RCT's Done on Any Vaccine

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Permalink Reply by Gina Tyler DHOM on January 14, 2010 at 5:48pm

YEs this is happening ,not on some other planet here in the USA
"Using kids as guinea pigs in potentially harmful vaccine experiments is every parents' worst nightmare. This actually happened in 1989-1991 when Kaiser Permanente of Southern California and the Centers for Disease Control (CDC) jointly conducted a measles vaccine experiment.

Without proper parental disclosure, the Yugoslavian-made "high titre" Edmonston-Zagreb measles vaccine was tested on 1,500 poor, primarily black and Latino, inner city children in Los Angeles.

Highly recommended by the World Health Organization (WHO), the high-potency experimental vaccine was previously injected into infants in Mexico, Haiti, and Africa. It was discontinued in these countries when it was discovered that the children were dying in large numbers.
Unbelievably, the measles vaccine caused long-term suppression of the children's immune system for six months up to three years. As a result, the immunodepressed children died from other diseases in greater numbers than children who had never received the vaccine. Tragically, African girl babies in the experiment were given twice the dose of boys, and therefore suffered a higher death rate. The WHO pulled the vaccine off the market in 1992.
Ironically, the E-Z measles vaccine tested by Kaiser on minority babies was supposed to increase immunity in younger infants. Instead, the vaccine produced the opposite effect.



"Worth Coolie Prost of Arlington, Virginia, is a biomedical research consultant and medical ethicist who terms what happened with the EZ measles vaccine a "silent tragedy." She reminds us that human experimentation has been performed on vulnerable populations throughout history, with informed consent standards being repeatedly ignored, despite laws designed to prevent this from happening. .........It is very unlikely that any of those deaths would ever have been linked to the vaccine ("high titre" Edmonston-Zagreb measles vaccine), since deaths were delayed.

They didn’t begin until six months after vaccination and they continued up until four years after vaccination. Additionally, the deaths were not from measles. Babies died of infections, diarrhea, malnutrition, and all the other things that Third World babies usually die of, because what the vaccine did in some babies, particularly girls, was cause a broad immunosuppression."---Worth Coolie Prost (Gary Null vaccine report)

Permalink Reply by Heidi Stevenson on January 14, 2010 at 6:37pm

Did you know that one of the primary methods used to study diseases using animals uses vaccine adjuvants to create the disease?

For example, rheumatoid arthritis is studied in mice by first inducing it in them by injecting them with collagen. It is well known that injecting this natural and normally harmless substance into mice will always cause rheumatoid arthritis. Thus, it must be well understood that injecting other natural substances, like squalene, cannot be defined as safe.

Yet, the claim is made that squalene cannot be harmful because it's an ingredient found in the body naturally.

I bring this up here because the so-called gold standard of RCTs is a fraud in every sense, just like the claim that squalene is safe. It's referred to when convenient. When it isn't, it's ignored. It's merely one method - and obviously, it isn't used with vaccines for one reason alone: If it were, then the fraud would become obvious. The claims that it has something to do with ethics are a farce, in light of the experiments that are already being done, as Gina noted here.

Permalink Reply by Vaikunthanath das Kaviraj. on January 14, 2010 at 7:11pm

Yes, did you see my blog on RCT's? Complete fraud.
I shall post here also the opinion of one English Lord, who is one of the few to make sense. He is saying also that there are more ways to skin the cat. He is a member of the Royal Society.

Permalink Reply by Vaikunthanath das Kaviraj. on January 14, 2010 at 7:13pm

http://www.politics.co.uk/opinion-formers/press-releases/royal-coll...

Royal College of Physicians: Sir Michael Rawlins attacks traditional ways of assessing evidence


Thursday, 16, Oct 2008 12:00

In this year's Harveian Oration*, delivered at the Royal College of Physicians, Professor Sir Michael Rawlins, Chair of the National Institute for Health and Clinical Excellence, argues that we need a new approach to analysing clinical evidence.

The evidence discussed in Sir Michael's Oration has only one purpose. It is the basis for informing decisions about the appropriate use of therapeutic interventions (including pharmaceuticals, devices and surgical procedures) in routine medical practice.

Such decisions have to be made at various levels but with critical consequences for patients, their families and society. They include the decisions that physicians make for individual patients as well as well as assessing whether interventions are safe, effective and cost effective for healthcare systems as a whole. Mistakes can have repercussions at all levels.

Randomised controlled trials (RCTs), long regarded at the 'gold standard' of evidence, have been put on an undeserved pedestal. Their appearance at the top of "hierarchies" of evidence is inappropriate; and hierarchies, themselves, are illusory tools for assessing evidence. They should be replaced by a diversity of approaches that involve analysing the totality of the evidence-base.

Si Michael outlines the limitations of RCTs in several key areas:

# Impossible - with treatments for very rare diseases where the number of patients is too limited

# Unnecessary - when a treatment produces a "dramatic" benefit - imatinib (Glivec) for chronic myeloid leukaemia

# Stopping trials early - interim analyses of trials are now commonly undertaken to assess whether the treatment is showing benefit and if the trial can be stopped early. Around 30% of recent trials in oncology have been stopped early for apparent benefit. Although the desire to stop trials early is understandable, the possibility that an interim analysis is a "random high" may be difficult to avoid - especially as there is no consensus among statisticians as to how best to handle this problem

# Resources - the costs of RCTs are substantial in money, time and energy - a recent study of 153 trials completed in 2005 and 2006 showed a median cost of over £3 million and with one trial costing £95 million. One manufacturer has estimated that the average cost per patient increased from £6,300 in 2005 to £9,900 in 2007

# Generalisability - RCTs are often carried out on specific types of patients for a relatively short period of time, whereas in clinical practice the treatment will be used on a much greater variety of patients - often suffering from other medical conditions - and for much longer. There is a presumption that, in general, the benefits shown in an RCT can be extrapolated to a wide population; but there is abundant evidence to show that the harmfulness of an intervention is often missed in RCTs.

Sir Michael argues that observational studies are also useful and, with care in the interpretation of the results, can provide an important source of evidence about both the benefits and harms of therapeutic interventions. These particularly include historical controlled trials and case-control studies but other forms of observational data can also reveal important issues.

Sir Michael rejects the trend to grade various kinds of clinical trials and studies on scales of merit which he says has come to dominate the development of some aspects of clinical decision making.

"Hierarchies attempt to replace judgement with an oversimplistic, pseudo-quantative, assessment of the quality of the available evidence."

Sir Michael believes that arguments about the relative importance of different kinds of evidence are an unnecessary distraction. What is needed instead is for "investigators to continue to develop and improve their methodologies; for decision makers to avoid adopting entrenched positions about the nature of evidence; and for both to accept that the interpretation of evidence requires judgement."

Notes to Editors

The Harveian Oration will take place at 5.30 pm on Thursday 16 October at the Royal College of Physicians, 11 St Andrews Place, Regent's Park, London NW1 4LE, and journalists are welcome to attend. For further information, a full copy of the Oration and to arrange interviews please contact RCP PR Manager Linda Cuthbertson on 020 7935 1174 ext.254, or e-mail Linda.Cuthbertson@rcplondon.ac.uk.

Michael Rawlins has been chairman of the National Institute for Health and Clinical Excellence (NICE) since its inception in 1999. NICE is responsible for assisting health professionals, in the NHS, to provide patients with the highest attainable standard of care; as well as advising the public health community on measures that are effective and cost effective in the prevention of ill health. He has seen the Institute grow from an organisation with no staff, no premises, no bank account and a nominal budget of £8.5 million a year to a body now employing over 270 people, with offices in London and Manchester, and an annual budget of £35 million, which is set to more than double over the next few years. From 1973 to 2006, he was the Ruth and Lionel Jacobson Professor of Clinical Pharmacology at the University of Newcastle where he undertook research into the safety and efficacy of new and established pharmacological treatments. At the same time he was consultant physician to the Newcastle University Hospitals where he practised clinical pharmacology and general internal medicine. He is now Emeritus Professor at the University of Newcastle and Honorary Professor at the London School of Hygiene and Tropical Medicine, University of London. He served as chairman of the Committee on Safety of Medicines (1993-8) and of the Advisory Council on the Misuse of Drugs (1998-2008) and he was appointed Knight Bachelor in 1999. He has previously delivered the Bradshaw (1986), William Withering (1994) and Samuel Gee (2006) lectures at the Royal College of Physicians.

* William Harvey, the eminent 17th Century physician who discovered the circulation of the blood, gave an indenture to the RCP in 1656 for an annual dinner to encourage friendship between Fellows and Members of the College at which there should be an oration "with an exhortation to the Fellows and Members of the said College to search and study out the secret of Nature by way of experiment". The College continues the tradition by inviting a leading doctor or scientist to give the Oration on issues relating to his or her own field of work.

Linda Cuthbertson

PR Manager

Royal College of Physicians

11 St Andrews Place

Regent's Park

London NW1 4LE

Tel: 020 7935 1174 ext.254, 0794 105 7494

Permalink Reply by Jennifer Hautman on March 13, 2010 at 1:37pm

This is very useful. Thanks for this!